Scientific papers

• Arnau J, Lauritzen C and Pedersen J (2006) Cloning strategy, production and purification of proteins with exopeptidase-cleavable his-tags. Nature Protocols 1:2326-2332 
  
  
• Mølgaard A, Arnau J, Lauritzen C, Larsen S, Petersen G and Pedersen J (2006) The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2. Biochemical J 401:645-650 
  
  
• Arnau J and Pedersen J (2006) A universal platform for the purification of therapeutic proteins using affinity tags: the use of engineered aminopeptidases for his-tag removal. Bioprocessing J 5:59-65
  
  
• Guevara T, Mallorquí-Fernández N, García-Castellanos R, García-Piqué S, Petersen GE, Lauritzen C, Pedersen J, Arnau J, Gomis-Rüth FX, Solà M (2006) Papaya glutamine cyclotransferase shows a singular fivefold beta-propeller architecture that suggests a novel reaction mechanism. Biol Chem 387:1479-1486
  
  
• Bondebjerg J, Fuglsang H, Valeur KR, Pedersen J, Naerum L (2006) Dipeptidyl nitriles as human dipeptidyl peptidase I inhibitors. Bioorg Med Chem Lett 16:3614-3617
  
  
• Arnau J, Lauritzen C, Petersen G, Pedersen J (2006) Current strategies for the use of affinity tags and tag removal for the purification of recombinant proteins. Prot Expr Purif 48:1-13
  
  
• Bondebjerg J, Fuglsang H, Valeur KR, Kaznelson DW, Hansen JA, Pedersen RO, Krogh BO, Jensen BS, Lauritzen C, Petersen G, Pedersen J, Naerum L (2005) Novel semicarbazide-derived inhibitors of human dipeptidyl peptidase I (hDPPI). Bioorg Med Chem 13:4408-4424 
  
  
• Jensen MR, Petersen G, Lauritzen C, Pedersen J, Led JJ. (2005) Metal binding sites in proteins: identification and characterization by paramagnetic NMR relaxation. Biochemistry 44:11014-11023
  
  
• Jensen MR, Lauritzen C, Dahl SW, Pedersen J, Led JJ (2004) Binding ability of a HHP-tagged protein towards Ni2+ studied by paramagnetic NMR relaxation: the possibility of obtaining long-range structure information. J Biomol NMR 29:175-185
  

   

• Sheth PD, Pedersen J, Walls AF, McEuen AR (2003) Inhibition of dipeptidyl peptidase I in the human mast cell line HMC-1: blocked activation of tryptase, but not of the predominant chymotryptic activity. Biochem Pharmacol 66:2251-2262
  

   

• Schäfer F, Schäfer A, Steinert K (2002) A highly specific system for efficient removal of tags from recombinant proteins. J Biomol Tech 13:158-171
  

   

• Turk D, Janjic V, Stern I, Podobnik M, Lambda D, Dahl SW, Lauritzen C, Pedersen J, Turk V, Turk B (2001) Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases. EMBO J 20:6570-6582
  

   

• Dahl SW, Halkier T, Lauritzen C, Dolenc I, Pedersen J, Turk V, Turk B (2001) Human recombinant pro-dipeptidyl peptidase I (cathepsin C) can be activated by cathepsins L and S but not by autocatalytic processing. Biochemistry 40:1671-1678
  

   

• Olsen JG, Kadziola A, Lauritzen C, Pedersen J, Larsen S, Dahl SW (2001) Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain. FEBS Letters 506:201-206
  

   

• Cigic B, Dahl SW, Pain RH (2000) The residual pro-part of cathepsin C fulfills the criteria required for an intramolecular chaperone in folding and stabilizing the human proenzyme. Biochemistry 39:12382-12390
  

   

• Dahl SW, Slaughter C, Lauritzen C, Bateman RC Jr, Connerton I, Pedersen J (2000) Carica papaya Glutamine Cyclotransferase belongs to a novel plant enzyme subfamily: cloning and characterization of the recombinant enzyme. Prot Expr Purif 20:27–36
  

   

• Pedersen J, Lauritzen C, Madsen MT, Dahl SW (1999) Removal of N-terminal polyhistidine tags from recombinant proteins using engineered aminopeptidases. Prot Expr Purif 15:389-400
  

   

• Lauritzen C, Pedersen J, Madsen MT, Justesen J, Martensen PM, Dahl SW (1998) Active recombinant rat dipeptidyl aminopeptidase I (cathepsin C) produced using the baculovirus expression system. Prot Expr Purif 14:434-442.